DAVID Documentation: Functionally Related Terms

This algorithm adopts kappa statistics to quantitatively measure the degree of agreement between two terms based on genes that are annotated or not annotated to them.

Gene List Report Interface 1 2 3 4 5 6 7 8 9 10 11
  1. Gene List
    Current gene list selected for view and background species being analyzed. Also show number of terms searched.
  2. Help and Switch to Classic Version
    Link to this help page and provides access to the legacy Gene List Report interface.
  3. Similarity Term Overlap
    Click to access a drop-down menu of overlap values. The minimum number of annotation terms overlapped between two genes in order to be qualified for kappa calculation. This parameter is to maintain necessary statistical power to make the kappa value more meaningful. The higher the value, the more meaningful the result is.
  4. Similarity Threshold
    Click to access a drop-down menu of theshrold values. The minimum kappa value to be considered significant. A higher setting will lead to more genes going unclustered, which leads to a higher quality functional classification result with fewer groups and fewer gene members. Kappa value of 0.3 starts giving meaningful biology based on our genome-wide distribution study. Anything below 0.3 has a good chance to be noise.
  5. Update Table
    After making adjustments to filtering options, click this button to update the table using the selected parameters.
  6. Similarity Score Legend
    General guide to understand the similarity scale of Kappa scores.
  7. The search box filters all table results in real time and the number of resulting terms is displayed.
  8. Export Options
    Results can be exported using Copy, Excel, CSV, or PDF. Exports reflect the current filtered and sorted view.
  9. Categories
    Categories of term results, indicating orginal source of information. (e.g. UP = uniprot). Click to sort by this value.
  10. Annotations
    Annotations available for each item. If available, hyperlinks lead users to original resources for further details. Click to sort by this value.
  11. Kappa
    Measurement of agreement between two sets of categorized data. The higher the value of Kappa, the stronger the agreement. Click to sort by this value. Click the value link to be directed to the Related Evidence page for this term. For more information, see the Related Evidence documentation page.