LHRI Presentations

2025 | 2024 |2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016		Last updated March 19, 2025
2025 Presentations
H. Imamichi, F. Scrimieri, SS. Mistry, B. Grund, HC Lane, JV. Baker. Transcriptionally Active Defective HIV-1 Proviruses Persist in All CD4 T Cell Subsets during ART. CROI 2025 Abst: Poster #349, San Francisco, CA, March 9-12, 2025
H. Sui, J. Bernbaum, H. Imamichi, HC. Lane, T. Imamichi. Extracellular Vesicles Secreted from the Cells Harboring HIV-1 Defective Provirus Initiate Inflammatory Cascades. CROI 2025, CROI2025 Abst: Poster #380, San Francisco, CA, March 9-12, 2025
2024 Presentations
A. Aioi, T. Imamichi, J. Kashiwakura, E. Ashitaka. Transfection of dsDNA induces cell senescence via ATR signaling pathway in human keratinocytes. 49th Conference of Japanese Society for Investigative Dermatology, Abst: P04-15/O04-24, Dec.6-8, 2024, Nagoya, Japan
H. Sui, S. Cachaco, W. Brunchy, M. Hao, and T. Imamichi. Manganese enhances antiviral cytokine inductions by driving an ATM -TBK1 phosphorylation signaling pathway. Cytokine 2024, October 20-23, (Poster Presentation. P3-IM052), Seoul, Korea
H. Imamichi, V. Natarajan, F. Scrimieri, M. Smith, Y. Badralmaa, M. Bosche, Jack Hensien, T. Buerkert, W. Chang, B.Sherman, K. Singh, H.C. Lane. Persistence of HIV-RNA in autopsy tissue samples from persons with HIV with suppressed viral loads. CROI 2024, March 3-6, (Poster Presentation 498), Denver, Colorado, USA
2023 Presentations
M. Milojevic, R. Z. Marandi, B. Sherman, W. Chang, J. D. Lundgren, D. D. Murray, C. R. Macpherson, P. Leung. Polygenic Interactive Discovery System: an interactive knowledgebase for exploring complex genetics networks. ASHG 2023; Nov 1-5, 2023. (Poster presentation. PB4541), Washington DC, USA.
Q. Chen, B. Sowrirajan, J. Yang, S. Laverdure, H. Sui, A. Mele, and T. Imamichi. IL-27-induced dendritic cells resist HIV infection via SPTBN1, autophagy, and YB-1 independent manners. Cytokine 2023; October 15-17, 2023. (Poster presentation. Abst. P1-102), Athens, Greece.
H. Sui, S Cachaco, M. Hao, W. Chang, and T. Imamichiu>. Cytoplasmic ATM mediates manganese-dependent TBK1 phosphorylation and enhances innate immune response. Cytokine 2023; October 15-17, 2023. (Poster presentation. Abst: P3-030), Athens, Greece.
T. Imamichi, H. Sui, J. Bernbaum, H.C. Lane, H. Imamichi. Recombination of "defective" proviruses to produce replication-competent HIV-1. IAS 2023, the 12th IAS Conference on HIV Science; Jul 23-26, 2023. (Poster presentation. Abst. 05726), Brisbane, Australia.
F. Scrimieri, E. Bastian, M. Smith, C. Rehm, C. Morse, J. Kuruppu, M. McLaughlin, J. Kovacs, H.C. Lane, H. Imamichi. Role of transcriptionally-active "defective" HIV-1 proviruses in immunological non-responders: a case-control study. IAS 2023, the 12th IAS Conference on HIV Science; Jul 23-26, 2023. (Poster presentation. Abst. 04595), Brisbane, Australia.
A .Aioi, T. Imamichi, and J.-I. Kashiwakura. The transfection of double-stranded DNA induces cell senescence in cultured human keratinocytes. First International Societies for Investigative Dermatology Meeting; May 10 - 13, 2023 Tokyo, Japan.
S. Laverdure, D. Kazadi, K. Kone, R. Ridzon for the InVITE Study Team. COVID-19 Seroprevalence in Vaccine-Naïve Populations in DRC, Guinea, Liberia and Mali. CROI; Feb 19 - 22, 2023 (Poster Presentation 917), Seattle, WA, USA.
2021 Presentations
S. Goswami, X. Hu, J. Yang, S. Laverdure, J. Qiu, Q. Chen, B.T. Sherman, W. Chang, and T. Imamichi. Identification of A Novel Anti-HIV miRNA in Interleukin-27-differentiated Macrophages. CROI; 1. 2021.Abst. 02161. (Oral presentation in Science Spotlight), Young investigator award.
2020 Presentations
B. T. Sherman, M. Hao, J. Qiu, X. Jiao, T. Imamichi, W. Chang. DAVID update-Expanded knowledgebase and analysis tools for the functional annotation of gene lists. CSHL Biological Data Science Conference; 2020 November 4 - November 6, Virtual Meeting, Poster 57.
H. Sui, Q. Chen, J. Yang, S. Srirattanapirom, and T. Imamichi. Manganese Enhances Ku70-STING mediated IFN-lambda 1 Induction by Increasing in phosphorylation of TBK1. Cytokine 2020; November 1-4, CYT20-1187.
S. Goswami, X. Hu, Q. Chen, J. Qiu, J. Yang, D. Poudyal, BT. Sherman, W. Chang, and T. Imamichi, A Comparative Study of Novel microRNAs Identified in Interleukin-27-Induced HIV-Resistant T Cells. Cytokine 2020; November 1-4, CYT20-1150.
H Imamichi, V Natarajan, F Scrimieri, M Smith, Y Badralmaa, M Bosche, J Hensien, T Buerkert, W Chang, B Sherman, K Singh, HC Lane. Multiple sanctuary sites for intact and "defective" HIV-1 in post-mortem tissues in individuals with suppressed HIV-1 replication: Implications for HIV-1 cure strategies. 23rd International AIDS Conference; 2020 July 6 - July 10, Virtual Meeting, Oral presentation OAA0404.
B. Sherman, X. Hu, K. Singh, L. Haine, J. Neaton, JD. Lundgren, T. Imamichi, W. Chang, H. Clifford Lane, for the INSIGHT Study Group. Genetic Determinants of hsCRP, D-dimer, and IL-6 in 3 Multiethnic HIV Cohorts. The 2020 Conference on Retroviruses and Opportunistic Infections; (Boston, Massachussetts), 2020 March 8 - March 11; Poster 195.
2019 Presentations
H. Sui, HC. Lane and T. Imamichi. Ku70, a Nuclear Protein Associated with Non-homologous End-joining (NHEJ) Pathway of DNA Repair, Translocates to the Cytosol upon Exogenous DNA Stimulation to Induce Type III Interferon Response. Poster presented at the Spring Research Festival at NCI-Frederick; 2019 May 1-2; Fort Detrick, Frederick, MD.
X. Hu, B. Sherman, J. Qiu, S. Laverdure, T. Imamichi. CLAP: a comprehensive lncRNA analysis pipeline. Poster presented at the Spring Research Festival at NCI-Frederick; 2019 May 1-2; Fort Detrick, Frederick, MD.
H. Sui, J. Yang, X. Hu, Q. Chen, and T. Imamichi. Identification of a unique RNA motif sequence that regulates an off-target effect by small RNA. Keystone Symposia: Small Regulatory RNAs; (Daejeon Korea), April 14 - April 18, 2019. Abs 1032.
H. Sui, HC. Lane and T. Imamichi. Ku70, A Nuclear Protein Associated with Non-homologous End-joining (NHEJ) Pathway of DNA Repair, Translocates to the Cytosol upon Exogenous DNA Stimulation to Induce Type III Interferon Response. Innate Immune Receptors: Roles in Immunology and Beyond; (Taipei, Taiwan), Mar 10 - Mar 14, 2019. Abst.
2018 Presentations
H. Sui, J.Yang, X. Hu, Q. Chen, H.C. Lane and T. Imamichi. siRNAs Containing a Unique 5-nucletide Motif Act as a Quencher of IFI16-mediated DNA Sensing in Innate Immune Response. Cytokine 2018; (Boston, MA), October 27-30, 2018. Abst. P247.
S. Laverdure, Z. Wang, K. Nagashima, H.C. Lane and T. Imamichi. IL-27 triggers autophagy in macrophages via a mTOR and LC3-Independent Manner. Cytokine 2018; (Boston, MA), October 27-30, 2018. Abst. P043.
S. Laverdure, Z. Wang, K. Nagashima, H.C. Lane and T. Imamichi. IL-27 induces autophagy during monocyte-to-macrophage differentiation through a novel LC3-independent pathway. Oral and Poster presentation. Immunology 2018; (Austin, TX), May 4-8. Abst. 164.7.
H. Sui, H.C. Lane and T. Imamichi. Human Ku70, a nuclear protein associated with non-homologous end-joining (NHEJ) pathway of DNA repair, is translocated to the cytosol upon exogenous DNA stimulation and serves as a DNA sensor to induce IFN-lambda 1 (Type-III IFN) via a STING dependent manner. Keystone Symposia. Cells vs. Pathogen: Intrinsic Defenses and Counter defenses; (Monterey, California), USA, March 23-26, 2018. Abs. 1048.
D. Poudyal, A. Herman, J. Adelsberger, J. Yang, X. Hu, Q. Chen, M. Bosche, B. T. Sherman, and T. Imamichi. A novel IL-27-stimulated microRNA, hsa-miR-6852 (miR SX4) induces necrosis in cervical cancer cells by downregulating the FoxM1 expression by unconventional microRNA pathway. Keystone Symposia. Noncoding RNAs: Form, Function, Physiology;(Keystone, Colorado), USA, Feb 25 - Mar 1, 2018.
2017 Presentations
Y. Saito, B. Sowrirajan, D. Poudyal, N. Noguchi, HL. Malech, H.C. Lane and T. Imamichi. Interleukin-27 Induces p47phox in Monocyte-derived Macrophages and Dendritic cells and Enhances the Potential of Reactive Oxygen Species Generation. Abstract presented at the Society for Redox Biology and Medicine 2017; 2017 November 29 - December 2; Baltimore, MD. Abs 321. [https://doi.org/10.1016/j.freeradbiomed.2017.10.334]
T. Izumi, D. Poudyal, J. Yang, X. Hu, M. Bosche, Q. Chen, W. Bruchey, R.G. Zamat, B.T. Sherman, H.C. Lane, and T. Imamichi. IL-27-inducible novel microRNA, hsa-mir-7705, predominantly elicits IFN-alpha from human monocyte-derived macrophages in a structure and sequence dependent manner. Poster presented at the 5th Annual Meeting of the International Cytokine & Interferon Society; 2017 October 29 - November 2; Kanazawa, Japan. Poster Abs. Mo-P11-12.
H. Sui, X. Hu, B.T. Sherman, H.C. Lane, and T. Imamichi. siRNA with a Unique 5-Nt Motif Potently Suppresses IFI16-Mediated Innate Immune Response to Intracellular DNA. Poster presented at the 5th Annual Meeting of the International Cytokine & Interferon Society; 2017 October 29 - November 2; Kanazawa, Japan. Poster Abs. Tu-P4-14.
X. Hu, Q. Chen, B. Sowrirajan, M. Bosche, T. Imamichi and B. T Sherman. MicroRNA Expression Profiling and Novel MicroRNA discovery in Interleukin-27 Treated Monocyte-derived Human Dendritic Cell. Poster presented at the 7th Genomics & Big Data Summit; 2017 September 26-27; San Diego, CA.
X. Jiao, H. Imamichi, T. Rehman, R. Nahar, R.L. Dewar H. C. Lane, T. Imamichi and B.T. Sherman. Self-Tuning Spectral Clustering for Full-length Viral Quasispecies Reconstruction with PacBio Long Reads. Poster presentation at the Proceedings of ACM-BCB; 2017 August 20-23; Boston, MA.
B. Sowrirajan, J. Yang, J. Adelsberger, M. Bosche, Q. Chen, C. Watkins, T.Izumi, H. Clifford Lane, and T. Imamichi. Interleukin-27 (IL-27) differentiates monocytes into HIV resistant dendritic cells: Identification of ANKRD22 as a novel inducible host restriction factor. Oral presentation at the 42nd annual meeting on Retroviruses; 2017 May 22-26; Cold Spring Harbor, NY.
T. Izumi, D. Poudyal, Q. Chen, X. Hu, BT. Sherman, and T. Imamichi. The Antiviral Mechanism of a Novel MicroRNA, miR 7705 in Macrophage induced by IL-27 Treatment. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
T. Rehman, A. Khan, H. Highbarger, P. Burbelo, B. Sherman, X. Hu, T. Imamichi, J. Metcalf , J. Beigel, C. Lane, M. Baseler, and RL. Dewar. A New Method to Test for Zika Virus? Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
H. Sui, M. Zhou, H. Imamichi, H. C. Lane and T. Imamichi. Identification of STING as an essential adaptor of Ku70 to initiate cytosolic DNA or DNA virus-mediated IFN-Λ1 innate immune response. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
X. Hu, Q. Chen, B. Sowrirajan, M. Bosche, T. Imamichi and BT. Sherman. Identification of Novel miRNAs and miRNA Expression Profiling in Interleukin-27 Treated Monocyte-derived Human Dendritic Cells. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
D. Poudyal, Q. Chen, J.W. Adelsberger, J. Yang, RL. Homung, HC. Lane, T. Imamichi. A DNA- and RNA- binding protein, Y-Box Binding Protein-1 (YB-1) is a novel host required factor in CD4 T cells regulated by post-translational modification by Interleukin-27 (IL-27). Poster presented at the Keystone Symposia, Modeling Viral Infections and Immunity; 2017 May 1-4; Estes Park, Colorado.
H. Sui, M. Zhou, H. Imamichi, H. C. Lane and T. Imamichi. Identification of STING as an essential adaptor of Ku70-medited IFN-Λ1 induction in sensing intracellular DNA. Poster presented at the Keystone Symposia, Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease (X5); 2017 March 19-23; Banff, Alberta Canada.
2016 Presentations
H. Sui, M. Zhou, X. Jiao, H. Imamichi, B.T. Sherman, H.C. Lane, and T. Imamichi. STING Is an Indispensable Adaptor in DNA Via Ku70-Mediated IFN-Λ1 Signalling Pathway. Poster presented at the Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2); 2016 May 8-12; Dresden, Germany.
B.T. Sherman, J.H. Beigel, X. Hu, J. Qiu, M. Bosche, J. Yang, R.A. Lempicki, H.C. Lane, R.T. Davey Jr., and T. Imamichi. Gene Expression Profiles Associated with a Recombinant Vesicular Stomatitis Virus Ebola Vaccine. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
J. Qiu, S. Swaminathan, A.W. Rupert, Z. Hu, J. Higgins, R.L. Dewar, R. Stevens, Q. Chen, C.A. Rehm, J.A. Metcalf, M.W. Baseler, B.T. Sherman, H.C. Lane, and T. Imamichi. Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
X. Jiao, T. Rehman, Q. Chen, H. Imamichi, R.L. Dewar, H.C. Lane, T. Imamichi, and B.T. Sherman. A Workflow for Viral Quasi-Species Analysis with Pacbio Long Reads. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
X. Hu, Q. Chen, B. Sowrirajan, H.C. Lane, T. Imamichi, and B.T. Sherman. Genome-Wide Identification of Novel Micrornas in Human Monocyte-Derived Dendritic Cells. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.